I turned 65 last year, and each year I get more and more interested in human health. For most people it happens around age 50, but I've always been a slow learner. It's critical in terms of the cost of health care.

I've had a very unusual background in science - not the usual route of planning on being a scientist from age 3. I think my story shows that success is more about personal motivation and determination than it is about where you were born or what your economic status was.

In the past, geneticists have looked at so-called disease genes, but a lot of people have changes in their genes and don't get these diseases. There have to be other parts of physiology and genetics that compensate.

My early years were hardly a model of focus, discipline, and direction. No one who met me as a teenager could have imagined my going into research and making important discoveries. No one could have predicted the arc of my career.

Illness is the doctor to whom we pay most heed; to kindness, to knowledge, we make promise only; pain we obey.

I really see that socio-economic constraints and pressure contribute to our mental health in a big way. You come to realize that it's all mental health.

I'm a clown, which could be a public health role. I'm really interested in moving our society away from a society needing Xanax and Prozac, and that is really feeling depressed, to one that is celebrating, and so I find just walking around in colorful clothes, people smile.

Cancer treatment is very expensive, and the process is painful and long. This is something that we have to collectively think about, on how to make it affordable.