The truth was I felt ugly growing up. I only really started feeling comfortable in myself when I was 40.

I suffer from low self-esteem. I had horrible self-esteem growing up. You really have to save yourself because the critic within you will eat you up. It's not the outside world - it's your interior life, that critic within you, that you have to silence.

Intelligence is sexy. Don't play dumb, especially young girls. Don't play dumb. And let people see that you are intelligent.

On a Friday night in 1983, I was in a taxi in New York riding home from dinner with friends. A drunk driver ran a red light and hit the cab, and I was thrown toward the glass partition. I tried to duck, but my face hit the glass, and the impact fractured my cheekbone, my eye socket, my collarbone and several ribs.

I'm very pro-science and pro-technology; I believe that these have been key drivers of progress in the world in the last centuries.

I would still describe myself as a hacker. I still remember feeling the magic, the sense of discovery, when I first connected to a bulletin board. It seemed like the world was somehow brighter, the greens were greener. Like I'd stepped through a portal to the other side. I knew back then that things would never be the same again for me.

But man has still another powerful resource: natural science with its strictly objective methods.

By 1954, as an assistant professor with a group of three graduate students, I was able to initiate more complex experimental projects, dealing with the structure, stereochemistry and synthesis of natural products. As a result of the success of this research, I was appointed in 1956, at age twenty-seven, as professor of chemistry.