I was a very efficient doctor. I would get rewarded with a lot more patients. By the end of my medical career, I had maybe 2,000 patients in my practice.

I wasn't sued out of medicine, I wasn't arbitrated out of the profession.

I always say 'Knocked Up' opened the doors, and 'Hangover' just burst it wide open. To this day, it's still surreal. And my wife's a doctor. All our friends are doctors - our close friends. And it's just that I have an odd job now. I think I'm like a doctor who had a detour, and I just have an odd job.

I never let on I was a comedian. I never acted out. It was really important to me, like, to not be Patch Adams. I was so super serious as a doctor, I would bark orders to my nurses. I was hard-core. I wanted to make sure I did my job right. I was perfectly trained to be a physician. You know, it wasn't a fluke. I worked hard at it.

Sometimes I would like the opportunity to do character-driven comedy and that's really what I was trying to do in Meet The Parents. I think in a way this is a more old fashioned type of comedy.

I've played such serious characters that no one sees me the way I actually am, which is completely cheesy and goofy, so it would be fun to do a romantic comedy and just have a good laugh.

I do find the sibling connection endlessly fascinating, as I do all family dynamics. I like how siblings seem to create their own parentless mini-civilization within a family, one that has its own laws, myths, language, humor, its own loyalties and treacheries.

All comedy is really talking about social issues and things that are affecting our lives.