Engineers love to optimize problems. Now I optimize logistical problems. I ask: 'What's the goal? What are our constraints? What is the optimal, elegant way to get to that goal within those constraints?' I break it down in terms of a data funnel: 'Where in the funnel are we inefficient?' That analytical background really helps.

I was one of the key people responsible for building Facebook's News Feed. When we launched it in 2006, users hated it. There were 'I Hate Facebook' groups; random people organized protests. We even hired a security team.

Cove is essentially a collaboration, coordination and communication tool for the administration of organizations and communities, from the Stanford Graduate School of Business Entrepreneurship Club to church groups and schools.

Women need to understand that it is possible to stay in the workforce. A lot of women decide to take a back seat in their professional careers even before they are pregnant or are ready to have children.

We are going to transform Britain's rail system from the worst in the world to the best. If you can do a few things like that, when the body gives out, you can say you've lived a good life.

I think the Tea Party movement is great. I think anybody who has been frustrated over the last few years with the Republicans and Democrats, when they were trying to grow government and have spending and we weren't focusing on creating jobs and get our private sector growing again, I think that's when people started to wake up.

I have never come across a technology that doesn't change. This is inevitable. You have to adapt your systems as technology develops.

We know cancer is caused ultimately via a link between the environment and genes. There are genes inside cells that tell cells to grow and the same genes tell cells to stop growing. When you deregulate these genes, you unleash cancer. Now, what disrupts these genes? Mutations.