We have to remain humble about our understanding of the brain, because even our most powerful tools remain pretty blunt instruments for decoding the brain. In fact, we still do not know how to decipher the basic language of how the brain works.

My philosophy is really based on humility. I don't think we know enough to fix either diagnostics or therapeutics. The future of psychiatry is clinical neuroscience, based on a much deeper understanding of the brain.

Sometimes, patients with serious mental illness, just as with other serious medical illnesses, require hospitalization. In the absence of available public or private hospital beds, there are few options.

For bipolar in adults, I think there's pretty good agreement about what this looks like. For bipolar in children, there is some considerable debate about where are the boundaries. At the mild end, are these just kids who are active? Is this the class clown at the very severe - is this something other than a mood disorder?