Government is truly beginning to embrace the power of innovation for the people and by the people, the idea that if government collaborates openly with and unleashes the ingenuity of the public, it will get much more done, much faster and at much lower cost than if government acted alone.

I was not a project manager who was managing and executing the day-to-day operational work of building HealthCare.gov. I didn't have the kind of comprehensive, detailed, deep knowledge of that project that a manager would have.

My job is to be tech entrepreneur-in-residence at the White House.

The Obama Administration cares deeply about innovation and about helping to make sure that geeks across the country, those coming up with new discoveries and exciting inventions - and creating jobs along the way - have the freedom and security to keep innovating.

I think that people are going to think of me however they want to think of me, whether it's female or gay or cancer or funny or unfunny.

Depend upon yourself. Make your judgement trustworthy by trusting it. You can develop good judgement as you do the muscles of your body - by judicious, daily exercise. To be known as a man of sound judgement will be much in your favor.

Look at the problem of drug-resistant TB in the world. Look at HIV in the world. What's going to be required for everybody in the long run is the ability to do complex health interventions in poor settings.

When I was doing standup, I always wanted to get out of the standup world and take it back into the theatrical world, like with 'No Cure For Cancer.'